A close reading of the three Bhavanakramah texts, written by Kamalasila, reveals that their author was aware of two competing concepts of meditation prevalent in Tibet at the time of their composition. The two concepts of meditation,associated with the Sanskrit words bhavana and dhyana, can be related respectively to the Indian and Chinese sides of the well-known debates at bSam yas. The account of the Mahayana path outlined in these texts implies an acceptance of the precedence of bhavana over dhyana. (...) In this paper I argue that Kamalasila advocated bhavana – a conception of meditation which encompasses non-conceptual dhyana, but which also includes a discernment of reality that is conceptual in nature. Such conceptual discernment should not be understood simply as a process of ordinary rational understanding but rather as constituting a special kind of meditative wisdom. A failure to recognize the subtle differences between Kamalasila’s employment of the terms dhyana and bhavana, along with his advocacy of the latter, could easily lead to mistranslation and, with this, a basic misunderstanding of his position. In particular, it could lead to a conception of insight that is overly intellectual in nature. Given the historically important role that these texts played in the formation of Tibetan Buddhism, the implications of such a misconception could be far-reaching. This paper attempts to clarify the key meditation terminology found in the Bhavanakramas as well as demonstrate the rationale for using ‘meditation’ as the default translation for bhavana. (shrink)

Like proper names, demonstratives, and definite descriptions, pronouns have referential uses. These can be 'essentially indexical' in the sense that they cannot be replaced by non-pronominal forms of reference. Here we show that the grammar of pronouns in such occurrences is systematically different from that of other referential expressions, in a way that illuminates the differences in reference in question. We specifically illustrate, in the domain of Romance clitics and pronouns, a hierarchy of referentiality, as related to the topology of (...) the grammatical phase. Our explanation is based on extending the 'Topological Mapping Hypotheses' of Longobardi and Sheehan & Hinzen. The extended topology covers the full range of interpretations, from purely predicative to quantificational, to referential and deictic. Along this scale, grammatical complexity increases, and none of these forms of reference is lexical. This provides evidence for the foundational conclusion that the source of essential indexicality is grammatical rather than lexical, semantic or pragmatic. (shrink)

Scholars and environmentalists in the industrialized nations have repeatedly deplored the destruction of tropical forests as a byproduct of economic development. Their position is based upon scientific, economic, and ethical arguments. Proponents of economic development from the tropical nations recognize that its immediate benefits are enjoyed by their own relatively poor populations while the benefits of habitat preservation are enjoyed by the world as a whole. So far, few institutional mechanisms have been developed that can reconcile the competing perspectives. In (...) addition to reviewing the arguments in favor of and against habitat preservation, this paper proposes some innovative institutions that can both satisfy developmental aspirations and account for the global benefits of habitat preservation. (shrink)

I propose that a distinction can be drawn between two fundamental kinds of racism: own-race-present racism and own-race-absent racism. In own-racepresent racism, the race of the racist figures as a term in her racist thinking; in own-race-absent racism it does not. While own-race-present racism might conform readily to commonsense understandings of racism, own-race-absent racism less clearly does. I provide evidence that these two kinds are there to be identified and raise considerations regarding the benefits, both theoretical and practical, of adopting (...) the less-obvious concept of own-race-absent racism. (shrink)

This paper aims to lay bare the underlying logical structure of early Buddhist moral thinking. It argues that moral vocabulary in the Pali Suttas varies depending on the kind of agent under discussion and that this variance reflects an understanding that the phenomenology of moral experience also differs on the same basis. An attempt is made to spell this out in terms of attachment. The overall picture of Buddhist ethics that emerges is that of an agent-based moral contextualism. This account (...) does not imply that the prescription for moral conduct differs according to class of agent, but rather that the correct description of moral experience does. Further it implies that the descriptions of the moral experiences of different classes of agent differ phenomenologically, rather than in terms of overt behavioral characteristics. While most of the discussion is centered on the distinction between ordinary persons and disciples in higher training, the paper concludes with a brief exploration of the problematic moral experience of the arahat. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The War with God: Theomachy in Roman Imperial Poetry by Pramit ChaudhuriMartin T. DinterPramit Chaudhuri. The War with God: Theomachy in Roman Imperial Poetry. Oxford: Oxford University Press, 2014. xvi + 386 pp. Cloth, $74.We are all fighting our own demons, but some of us—so Chaudhuri tells us—are even fighting our own gods. Accordingly, a wide range of theomachs and their representation in classical literature fills the ranks (...) of this excellent book that will certainly elbow its way onto Mt. Olympus to sit comfortably next to divine Feeney (1991 and 1998) and sublime Hardie (1986 and 1993). Indeed, Chaudhuri transcends the scope of Feeney (1991) by including not only Senecan (and Attic) tragedy but also texts and contexts ranging from panegyric to philosophy and from lyric to historiography.Chaudhuri’s book falls into three parts. Its first three chapters cover theomachy in Greek poetry (Homer and Attic tragedy), as well as the development of theomachy in Augustan epic, with chapters on Lucretius and Vergil and Ovid. Here, Chaudhuri introduces some of the main patterns and contexts that will be developed in later imperial poetry. Chaudhuri also states clearly what will not be covered here at length: the voyage myths of the Odyssey and the Argonauts, Aristophanes’ Birds, and the (pseudo-) Aeschylean Prometheus Bound. Part 2 covers Neronian literature with Seneca’s Hercules Furens and Lucan, while Part 3 focuses on the Flavian era, with Silius and Statius. Statius’ Capaneus forms a highpoint amongst the theomachs and thus deservedly receives extra attention. Chaudhuri rounds off the Flavian section with a chapter on the politics [End Page 177] of theomachy, in which he samples theomachy as a trope for the confrontation between subject and ruler, ruler and god, rival emperors and the confrontation of dynasties. After all, the Flavian poets had witnessed the principate develop over time, the struggles for the throne, and the rise and fall of dynasties. This is followed by a titillating epilogue showcasing how the themes developed in the previous chapters that breach the divide between mortal and immortal (such as fame, equanimity, skepticism, and poetic and imperial apotheosis) echo through the centuries. Rarely, however, do we find simple didactic moralism. Instead, “the theomach is instrumental in generating a dialogue on the broader symbolism of fighting the gods, its stakes and implications” (323). Chaudhuri can but hint at the rich afterlife of the theomach across Europe from the fifteenth to the seventeenth centuries, a subject that would fill a second volume. He nevertheless whets the reader’s appetite by pointing to Milton’s Paradise Lost and Samson Agonistes, Ariosto’s Orlando Furioso, Christopher Marlowe’s Tamburlaine, Dante’s Inferno, and Tasso’s Gerusalemme Liberata, as well as a host of epigraphs to each chapter, and concludes with a glance at the twentieth and twenty-first centuries with Philip Pullman’s His Dark Materials, Richard Dawkins versus God, and modern physicists’ search for a God particle.Chaudhuri sets the volume off by contrasting theomachy with gigantomachy. While the feats of the Giants “remain far distant in time from the activities of humankind … the theomach speaks the language of humanity … offering a richer context for his radical aspirations and … inviting the audience to adopt an alternative view on the theological status quo” (5). He also places theomachy in its cultural context when he follows Momigliano’s (1984) suggestion that under Augustus poetry replaced antiquarianism and philosophy as the primary genre in which to think about the gods. The figure of the contemptor divum (despiser of the gods) thus comes to embody the contrast between piety and impiety which itself is grounded in the empirical basis of Roman religion. But rather than testing methods of communication with the divine, as the Romans so often did with divinatory practices and ritual protocols, the contemptor divum tackles the question of whether it is possible to know the divine at all and whether the gods even exist. “By placing these conflicts at the heart of their works, the epic poets expanded the cultural conversation to include the testing of the divine in the Romans’ attempts to make sense of the epistemological, theological, and political concerns pertaining... (shrink)

The present article aims to explain Kamala??la’s understanding of the nature of insight, specifically considering it as the ‘discernment of reality’ -- a technical term identified with insight in the author’s well known Bh?van?krama? texts. I approach my analysis of bh?ta-pratyavek?? from three different angles. I begin by providing a rationale for its translation. This is followed by an account of Kamala??la’s reading of key passages in the La?k?vat?ra S?tra describing the process to which the term refers. Here the aim (...) is to illustrate Kamala??la’s understanding of bh?ta-pratyavek?? as it is actually experienced in meditation. The final section examines bh?ta-pratyavek?? in relation to other important technical terminology employed in the course of making arguments against his historical rival in debate, the Ch’an monk Mo ho yen. By providing these three different perspectives on the same process it is my hope that both scholars and practitioners will be able to more fully comprehend and benefit from the instructions provided by the ancient master Kamala??la. (shrink)

This article makes the case for the importance of epigram, in terms of both form and content, for Valerius Flaccus' Argonautica. In the battle scenes of Books 3 and 6, in particular, recurrent allusions to epigrammatic themes unveil Valerius' poetics of epigram that evoke the dead for poetic purposes. As part of this, the apostrophe te quoque serves as an epitaphic gesture that marks the Argonautica, with its recurrent civil war imagery, as an epitaph on the golden age. In addition, (...) Valerius employs these epitaphic markers as an organising device, a narrative "glue" that makes the Iliadic and the Odyssean parts of his narrative hang together. (shrink)

The present article aims to explain Kamala??la’s understanding of the nature of insight, specifically considering it as the ‘discernment of reality’ -- a technical term identified with insight in the author’s well known Bh?van?krama? texts. I approach my analysis of bh?ta-pratyavek?? from three different angles. I begin by providing a rationale for its translation. This is followed by an account of Kamala??la’s reading of key passages in the La?k?vat?ra S?tra describing the process to which the term refers. Here the aim (...) is to illustrate Kamala??la’s understanding of bh?ta-pratyavek?? as it is actually experienced in meditation. The final section examines bh?ta-pratyavek?? in relation to other important technical terminology employed in the course of making arguments against his historical rival in debate, the Ch’an monk Mo ho yen. By providing these three different perspectives on the same process it is my hope that both scholars and practitioners will be able to more fully comprehend and benefit from the instructions provided by the ancient master Kamala??la. (shrink)

While outcomes for children with T-cell acute lymphoblastic leukemia have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid resistance is more common than resistance to other chemotherapies at relapse. In addition, failure to clear peripheral blasts during a prednisone prophase correlates with an elevated risk of relapse in newly diagnosed patients. Here we show that intrinsic GC resistance is present at diagnosis in early thymic precursor T-ALLs as well as in a subset (...) of non-ETP T-ALLs. GC-resistant non-ETP T-ALLs are characterized by strong induction of JAK/STAT signaling in response to interleukin-7 stimulation. Removing IL7 or inhibiting JAK/STAT signaling sensitizes these T-ALLs, and a subset of ETP T-ALLs, to GCs. The combination of the GC dexamethasone and the JAK1/2 inhibitor ruxolitinib altered the balance between pro- and anti-apoptotic factors in samples with IL7-dependent GC resistance, but not in samples with IL7-independent GC resistance. Together, these data suggest that the addition of ruxolitinib or other inhibitors of IL7 receptor/JAK/STAT signaling may enhance the efficacy of GCs in a biologically defined subset of T-ALL.Leukemia advance online publication, 30 May 2017; doi:10.1038/leu.2017.136. (shrink)

This paper continues a recent exchange in this journal concerning explanationist accounts of epistemic justification. In the first paper in this exchange, Byerly argues that explanationist views judge that certain beliefs about the future are unjustified when in fact they are justified. In the second paper, McCain defends a version of explanationism which he argues escapes Byerly’s criticism. Here we contribute to this exchange in two ways. In the first section, we argue that McCain’s defense of explanationism against Byerly’s objection (...) is unsuccessful. Then, in the second section, we develop an independent objection to explanationism from a different direction. If our arguments in each section are sound, then not only do explanationist accounts of epistemic justification judge beliefs that are justified to be unjustified, but they judge beliefs that are unjustified to be justified. Explanationism faces problems on both sides. (shrink)

'Why did the window break when it was hit by the stone? Because the window is brittle and the stone is hard; hardness and brittleness are powers, dispositional properties or dispositions.' Dispositions are essential to our understanding of the world. This book is a record of the debate on the nature of dispositions between three distinguished philosophers - D. M. Armstrong, C. B. Martin and U. T. Place - who have been thinking about dispositions all their working lives. Their (...) distinctive accounts cover many of the issues surrounding dispositions such as the nature of mind, matter, universals, existence, laws of nature and causation. Dispositions illuminates this central topic in analytic philosophy and at the same time highlights deeper concerns of metaphysics. (shrink)

This fascinating study offers a complete interpretation of the philosophies of both Nietzsche and Wittgenstein. It finds in Nietzsche's philosophy an expression of the scepticism and relativism of the modern world to which he gave the name «nihilism.» If Nietzsche's conclusion that «there is no truth» poses the basic problematic of modernity, Professor Martin understands Wittgenstein's philosophy as addressing, in a radically new way, the overcoming of this nihilism. Martin offers a new interpretation of Wittgenstein's life work as (...) focusing on «the groundlessness of the human situation» and as restoring «truth» to its legitimate place within the conventions of language. The final chapter explores the spiritual implications for modern man of seeing clearly «the limits» of human language. (shrink)

Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

Giovanni Sartori (1924-2017) was a founder and icon of contemporary political science. A number of his books and articles have become part of the theoretical and conceptual basis of the field, and of social science in general. This volume brings together selected essays that examine Sartori as a scholar, university professor and intellectual. It is unique in covering all three aspects of Sartori's academic work: comparative politics, social science methodology and political theory. General overviews of Sartori's contribution to political science (...) are complemented by chapters that focus on specific areas of his interest; and Sartori's theoretical and methodological contributions are examined alongside his extensive public appearances, which remain little known outside Italy. (shrink)

Response to commentaries on “The Transmission Sense of Information” Content Type Journal Article Pages 195-200 DOI 10.1007/s10539-011-9257-3 Authors Carl T. Bergstrom, Department of Biology, University of Washington, Seattle, WA 98195-1800, USA Martin Rosvall, Integrated Science Lab, Department of Physics, Umeå University, 901 87 Umeå, Sweden Journal Biology and Philosophy Online ISSN 1572-8404 Print ISSN 0169-3867 Journal Volume Volume 26 Journal Issue Volume 26, Number 2.